Guerendo, SF, flashed as a rookie relief back but shoulder issues linger. His capacity to stay healthy dictates his Week 1 role and overall fantasy value in SF’s crowded backfield.

Guerendo adds speed and big-play potential as the third option behind MC and Robinson. In 2025, his role is planned in explosive packages and as a change-of-pace back, particularly with Samuel out, to keep San Francisco’s rushing attack unpredictable.

Guerendo’s value drops with Robinson in San Francisco; last season he flashed upside, but Robinson's arrival reduces his playing time to mostly special-teams and depth carry scenarios unless injuries strike the top backs.

Guerendo’s elite athleticism keeps him in the SF RB mix, but health has been an ongoing issue, limiting him to fringe depth behind McCaffrey. Shanahan could turn to Guerendo in a pinch for big plays, especially if Guerendo shows up in practice with improved hands and pass protection, keeping him on the roster as a potential RB3 with upside.

Guerendo’s shoulder injury tightens SF’s backfield, elevating Robinson’s immediate upside if Guerendo is unavailable. Guerendo’s health status drives the depth chart and weekly touches, making him a variable piece in Week 1 and beyond.